Estimating the number of genetic mutations (hits) required for carcinogenesis based on the distribution of somatic mutations
Fig 3
Number of hits estimated by the multi-combination multi-hit model depends on the distribution of somatic mutations.
(a)-(c) Examples of three cancer types exhibiting distinct distributions and the predicted probability distribution for the optimal model, showing a corresponding difference in the number of hits. S1–S3 Figs show the distributions for the 17 cancer types with at least 200 samples.