Dynamic balance between vesicle transport and microtubule growth enables neurite outgrowth
Fig 4
Simulation of vesicle transport and microtubule growth during neurite outgrowth.
(A-B) We identified a set of kinetic parameters (S7 Table) that allows neurite outgrowth via coordinated neurite shaft (A) and microtubule bundle growth (B) with a velocity of 10 μm/h. (C) The growing neurite shaft cytoplasm (NSC) within the growing neurite acts as a sink for anterograde and retrograde vesicles, causing an accumulation of vesicles within this compartment. (D) Our identified set of kinetic parameters allows NOG without violation of the model constraints that we selected to define physiological outgrowth conditions.