Dynamic balance between vesicle transport and microtubule growth enables neurite outgrowth
Fig 2
Top-down based SCP modelling of whole cell dynamics.
Our pipeline for the generation of dynamical models that allow the analysis of relationships between sub-cellular processes (SCPs) during whole cell responses consists of two major steps. First, we build multicompartmental ODE models for the simulation of SCP activities that are based on literature curated data (Step 1a-d). In the second step we develop analytical predictions for kinetic parameters at steady state that allow a systematic analysis of SCP interactions (Step 2a-d).