Identification of pathways associated with chemosensitivity through network embedding
Fig 1
Global analysis of correlations between basal gene expression and compound response.
(A) Heatmap of the Pearson correlation coefficient between genes (expression) and compounds (chemosensitivity, measured by AUC values). (B) Histogram of the number of compounds associated with each gene. The y-axis shows the number of genes associated with k compounds, where k is shown on the x-axis. (C) Histogram of the number of genes associated with each compound. The y-axis shows the number of compounds associated with k genes, where k is shown on the x-axis. (D) Histogram of the number of compounds significantly associated with each pathway (Fisher’s exact test FDR < 0.05). (E) Histogram of the number of pathways significantly associated with each compound (Fisher’s exact test FDR < 0.05).