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Robustness of respiratory rhythm generation across dynamic regimes

Fig 9

Inputs to different nodes in the network provide distinct period control mechanisms.

Left column: pre-I is tuned to be intrinsically oscillatory (c11 = −0.03). Right column: pre-I is tuned to be intrinsically tonic (c11 = 0.01). All panels show period (black curve), inspiratory duration (blue curve), and expiratory duration (red curve) versus the value of a drive parameter relative to its baseline value (here labeled as 0) that was varied over the full range that preserved network rhythmicity. Drive parameters used are drive to early-I, c12 (top), drive to post-I, c13 (middle), and drive to aug-E, c14 (bottom). Drive parameters are fixed at c12 = 0.19, c13 = 0.58, c14 = 0.2 unless being varied. The same horizontal and vertical axis ranges are used in all panels.

Fig 9

doi: https://doi.org/10.1371/journal.pcbi.1006860.g009