A demonstration of modularity, reuse, reproducibility, portability and scalability for modeling and simulation of cardiac electrophysiology using Kepler Workflows
Fig 4
Simulated human ventricular single-cell model via kepler workflow with or without IKr reduction.
A. User configurations are shown in the left panels. Simulated single-cell action potential (AP–middle panel), and the time course of original IKr (control) during the AP (bottom). B—D Simulated single-cell action potentials (middle) with reduced IKr (bottom). GKr block ratio was set to 0.75 (B), 0.5 (C) and 0.25 (D) in 0D configuration setting (green arrows–left panels), corresponding to 25, 50 or 75% IKr block, respectively.