A demonstration of modularity, reuse, reproducibility, portability and scalability for modeling and simulation of cardiac electrophysiology using Kepler Workflows
Fig 2
The module “SingleCellUsrConf” is the User Configuration Module for single-cell simulations (SingleCell-Sim, see Fig 1). We created the user configuration module to allow users to control simulation constraints such as Na+ and rapid delayed rectifier K+ channel (IKr) blocker concentrations, ligand (β-blocker isoproterenol) concentration, CaMKII activity levels, number of beats, basic cycle length (BCL) i.e. heartbeat duration and other controls for single-cell simulation through workflow parameters.