An enriched network motif family regulates multistep cell fate transitions with restricted reversibility
Fig 11
Global sensitivity analysis for T cell developmental model.
Sensitivity analysis was performed for the 39 parameters in the T cell model. The transition actions between different states (SETP->DN2a and SDN3->DN2b) were calculated to quantify the sensitivity of parameters on the landscape. The Y-Axis represents the 39 parameters. The X-Axis represents the percentage of the transition action (S) changed relative to S without parameter changes. Here, SETP->DN2a represents the transition action from attractor ETP to attractor DN2a (cyan bars), and SDN3->DN2b represents the transition action from attractor DN3 to attractor DN2b (magenta bars). A. Each parameter is increased by 1%, individually. B. Each parameter is decreased by 1%, individually.