An enriched network motif family regulates multistep cell fate transitions with restricted reversibility
Fig 1
Illustration of multistep cell fate transition.
A. transition from one cellular state to another via two intermediate states. Dashed arrow indicates the limited reversibility of each transition. B. stepwise changes of the levels of two transcription factors during the multistep transitions involving four states. C. metaphoric energy landscape depicting the four-attractor system. Colors for cell states and transition arrows in B and C match those in the illustration in A.