Pan-cancer association of a centrosome amplification gene expression signature with genomic alterations and clinical outcome
Fig 2
CA20 is associated with different breast cancer clinical and molecular features.
(a-h) CA20 score distribution per (a,e) sample type, (b,f) histological and (c,g) PAM50 molecular subtype, and (d,h) tumour stage for (a-d) TCGA breast cancer and (e-h) METABRIC samples. Black points and lines represent the median +/- upper/lower quartiles. Number of samples used in each violin is shown within brackets. *** p-value < 0.001, **** p-value < 0.0001 and n.s. non-significant (Wilcoxon rank-sum test). (i-j) Luminal B and basal-like human breast carcinomas display higher levels of centrosome amplification (CA). (i) Illustration of the procedure to quantify CA in patient samples. (j) Percentage of cells displaying CA in breast tumours from the different PAM50 molecular subtypes (29 luminal A, 3 luminal B, 3 HER2 and 13 basal-like). Between 5 and 107 cells were analysed for each patient. * p-value < 0.05, *** p-value < 0.001 and n.s. non-significant (Wilcoxon rank-sum test).