Pan-cancer association of a centrosome amplification gene expression signature with genomic alterations and clinical outcome
Fig 1
The pan-cancer landscape of centrosome amplification-associated gene expression.
(a) For each sample, the CA20 score was calculated as the sum of the normalized (log2 median-centred) expression levels of the 20 signature genes. (b) CA20 score distribution across tumour samples of all TCGA cancer types. Cohorts are ordered by their median CA20 score. Black points and lines represent the median +/- upper/lower quartiles. (c) Tumour samples have higher CA20 levels in all 15 cancers with both tumour and matched-normal samples available (at least 10 samples per sample type; False Discovery Rate (FDR) < 0.0001, Wilcoxon rank-sum test). CA20 score distributions of tumour and normal samples are represented in red and blue, respectively. ACC: adrenocortical carcinoma; BLCA: bladder urothelial carcinoma; BRCA: breast invasive carcinoma; CESC: cervical squamous cell carcinoma and endocervical adenocarcinoma; CHOL: cholangiocarcinoma; COADREAD: colon and rectum adenocarcinoma; DLBC: lymphoid neoplasm diffuse large B-cell lymphoma; ESCA: oesophageal carcinoma; GBM: glioblastoma multiforme; HNSC: head and neck squamous cell carcinoma; KICH: kidney chromophobe; KIRC: kidney renal clear cell carcinoma; KIRP: kidney renal papillary cell carcinoma; LAML: acute myeloid leukemia; LGG: low-grade glioma; LIHC: liver hepatocellular carcinoma; LUAD: lung adenocarcinoma; LUSC: lung squamous cell carcinoma; MESO: mesothelioma; OV: ovarian serous cystadenocarcinoma; PAAD: pancreatic adenocarcinoma; PCPG: pheochromocytoma and paraganglioma; PRAD: prostate adenocarcinoma; SARC: sarcoma; SKCM: skin cutaneous melanoma; STAD: stomach adenocarcinoma; TGCT: testicular germ cell tumours; THCA: thyroid carcinoma; THYM: thymoma; UCEC: uterine corpus endometrial carcinoma; UCS: uterine carcinosarcoma; UVM: uveal melanoma.