Predicting kinase inhibitors using bioactivity matrix derived informer sets
Fig 3
A comparison of models with respect to compound ranking performance as assessed by active enrichment in the top 10% of ranked compounds.
Each model was evaluated on 224 targets through PKIS1 leave-one-target-out validation. NEF10 represents the fold-enrichment of actives in top 10% above random that is normalized by dividing by the maximum theoretical fold-enrichment that could be achieved at the 10% threshold for the target of interest.