Controlling seizure propagation in large-scale brain networks
Fig 4
Clinical history: occipital epilepsy type (left size). EZ region: Lateral occipital cortex. PZ prediction: Fusiform gyrus, Superior parietal cortex, Inferior temporal gyrus, Inferior parietal cortex, Pericalcarine, Lingual gyrus. PZ clinical prediction: Inferior parietal cortex, Superior parietal cortex. Lesions: links between regions LOC-FuG, LOC-SPC, LOC-ITG, LOC-IPC, LOC-PC, LOC-LgG must be cut in order to stop the seizure (lesions are performed in correspondence of the time identified by the dashed blue line). Upper panels: Time series generated by the implemented brain network model with the connectome of patient CJ. On the left the PZ (blue curves) is recruited immediately after the seizure (red curve) is emitted; on the right the recruitment is no more possible after the targeted disconnection is performed. Lower panel: Seizure events as a function of time. The connectivity matrix consists of 88 nodes and the EZ corresponds to 21. Seizures emitted by node 21 are highlighted in red, while the others are given in black. Green dashed line corresponds to the time at which lesions occur. The blue ellipse highlights the moment in time at which the PZ is recruited after the seizure emitted by the EZ.