Integrated structural variation and point mutation signatures in cancer genomes using correlated topic models
Fig 2
Predictive log-likelihood benchmark.
SNV and SV signature per-mutation predictive log likelihood means ± standard error (n = 50) for: a 2–12 signatures, b a range of mutation count fractions, and c MMCTM with estimated or fixed Gaussian covariance matrix. NMF: applied to raw counts, NMF-norm: applied to normalized counts.