IRIS-EDA: An integrated RNA-Seq interpretation system for gene expression data analysis
Fig 4
(A) Sample dendrogram and color bar representing optimized identified clusters for the WGCNA method of clustering on the scRNA-Seq example data. The dendrogram shows the 2- and 4-cell samples clustering together, with the Late Blastocysts forming a unique cluster. (B) The first three biclusters were generated using QUBIC on the IRIS-EDA server. The first two biclusters (69 and 49 genes) show the grouping of Oocyte, Zygote, and 2- and 4-cell samples and Oocytes, Zygote, and 2-, 4-, and 8-cell samples, respectively. The third bicluster (52 genes) separates the Late Blastocysts from the other samples. These three biclusters demonstrate the expression similarity between the Oocyte, Zygote, and multi-cell samples relative to the Late Blastocyst samples over numerous gene sets.