3D spatial organization and network-guided comparison of mutation profiles in Glioblastoma reveals similarities across patients
Fig 6
Proteins having mutations in their interfaces and the spatial arrangement of the mutations.
(A) The degree distribution of the proteins in the interactome having at least one mutation in the interface region are classified based on the 3D patch organization. Three classes, namely, proteins having multiple patches, single patch and without any patch but only singleton are on the x-axis and log10 of the degree of each protein is on the y-axis. High degree proteins (hubs) in interactome have tendency to include multiple patches on their interface regions. (B) The hub proteins have more interface mutations locating inside the patches. Only the proteins having at least one patch on their interface regions are shown.