A saturated reaction in repressor synthesis creates a daytime dead zone in circadian clocks
Fig 3
Dependence of the dead zone length on the Michaelis constant for nuclear protein degradation Km.
(A) Phase sensitivity –Zz and (B) time series of the levels of nuclear protein z for different values of Km. (C) Dead zone length Ld (top) and the maximum and minimum values of the phase sensitivity –Zz(max) and –Zz(min) (bottom) as a function of Km. In (A) and (C), the phase sensitivity is normalized by the period of oscillation Tp. (D) Time series of transcription rate 1/(1+(z/K1)n) in Eq (1) for different values of Km. Values of reaction parameters are listed in S1 Table.