Spatial clustering and common regulatory elements correlate with coordinated gene expression
Fig 5
Mouse ESC-CN system shows a similar enhanced tendency of physical proximity for co-regulated genes with similar expression patterns.
(A) Schematic diagram of the development from ESC to CN cells. (B) Dynamic regulatory map obtained through the DREM2 analysis. (C) Heat map of intra- (diagonal) and inter- (off-diagonal) HMM class gene densities within the first shell of radial distribution relative to the corresponding densities of all genes (as control) in ESC cells or CN cells (i.e., ). (D) Gene densities of all HMM classes within the first shell of radial distribution relative to the corresponding densities of all genes (i.e.,
)) in ESC cells or CN cells.