Drug combination sensitivity scoring facilitates the discovery of synergistic and efficacious drug combinations in cancer
Fig 4
Identification of true synergistic and true antagonistic drug combinations.
(A) The ROC curves for the S synergy scores to detect true synergistic and antagonistic drug combinations. (B) The S-S plot for all the drug combinations. The drug combinations with the 75th percentile and above for both the CSS and the S scores were highlighted in red to be considered as the prioritized hits for further experimental validation in a confirmatory screen using a full dose-response matrix design.