Drug combination sensitivity scoring facilitates the discovery of synergistic and efficacious drug combinations in cancer
Fig 3
The top important features by Elastic Net for each cell line.
Cell-line independent as well as cancer subtype-specific features can be identified by evaluating the regression coefficients of the Elastic Net model. Features such as TOP1MT, TOP2A/B has shown consistently positive coefficients as compared to features such as AKT1/2/3 which showed cancer subtype specificity in breast cancer (indicated as arrows).