Modelling the transport of fluid through heterogeneous, whole tumours in silico
Fig 9
Normalization of vascular hydraulic conductance, oncotic reflection coefficient and interstitial hydraulic conductivity, and stabilisation of vessel diameters to physiological values in (a, b) GL261 and (d, e) LS147T tumours.
(a, d) Planar contour plots of IFP and interstitial fluid speed (IFS) for the baseline (top) and normalised (bottom) predictions. (b, e) Predictions of normalised interstitial fluid spatial maps (left) and IFV (right—with greyscale perfusion underlaid) where the isotropic pixels are ∼ 140 μm wide. For comparison, equivalent {X,Y}-planes for baseline simulations can be viewed in Fig 4a and 4b, respectively. (c) A comparison of change in the source density, the ratio between sources and sinks (= [n − m]/[n + m] where n and m are the sum of sources and sinks, respectively, in the tumour region), across GL261 and LS147T (blue) pre- and (orange) post-normalization.