Modelling the transport of fluid through heterogeneous, whole tumours in silico
Fig 5
Sensitivity of the computational framework.
(a, e) Cross-sectional slice from the core of the (top) GL261 and (bottom) LS147T tumours, showing standard deviation of intravascular pressures (mmHg) across all 12 simulations. (b, f) the mean segment pressure error between consecutive iterations for the (top) GL261 (top) and (bottom) LS147T networks. (c, g) IFP distribution from the centre of the tumour to its periphery for a maximum spacing of (blue) 10 and 25 μm and (orange) 50 and 100 μm for GL261 and LS147T, respectively. (d, h) IFP distributions for the source radii set to the minimum vessel radius multiplied by a factor of (blue) 10−1, (red) 100 and (yellow) 101. Note, error bars correspond to standard deviation.