Modelling the transport of fluid through heterogeneous, whole tumours in silico
Fig 4
Simulated fluid transport through the interstitium in GL261 and LS147T tumours.
(a, b) (Left) Predicted interstitial fluid pressure (IFP) fields for {X,Y}-planes through the tumours, emulating the traditionally high pressure in the tumour core but with predicted spatial heterogeneities. (Middle) Simulated interstitial perfusion maps discretised into ∼ 140 μm2 pixels. Results replicate the traditionally elevated perfusion existing at the periphery of the tumours. (Right) Interstitial fluid velocity (IFV, overlaid onto greyscale image of interstitial perfusion) predictions depicting spatial interstitial flow heterogeneities across the entire tumours. Note, perfusion and interstitial fluid velocity maps are shown for the central slice in the interstitial fluid pressure graphics. (c, d) Fitted curves with error bars indicating standard deviation for (left) IFP and (right) IFV in (c) GL261 and (d) LS147T, plotted against normalised radius, corresponding to the simulations shown in (a, b).