Modelling the transport of fluid through heterogeneous, whole tumours in silico
Fig 2
(a, b) The optimisation scheme used to assign boundary conditions to the tumour networks.
(a) The process to simulate physiological tissue perfusion. (b) The flowchart for the subroutine “Assign Pressure Conditions” given in (a). (c) Perfusion through a tumour is calculated by generating a convex hull across the surface of the tumour to accurately extract tumour volume. (d) Discretising the hull into a finer mesh and calculating IFP at coupled points across, and normal, to the tumour hull. (e) A sphere packing algorithm is then applied to the points on the tumour surface with inflow averaged across the great circles of each sphere, enabling an approximation of perfusion.