Maps of variability in cell lineage trees
Fig 1
Illustration of pedigree data.
Shown are 5 sample pedigrees from each of the 3 lineage types. Each pedigree originates from a different founder cell and is, for compactness, drawn as a radial tree. Each node on the tree represents a cell, where node color reflects the strength of the cell phenotype under analysis (liftetime-averaged cell size for T cells, PHA-4 expression intensity for C. elegans). For T cells the root node is the naive cell while for the worm lineage the root node is the zygote (labelled P0). The absence of a node on the tree represents a missing data point. Labels for each worm cell position are given in Section S1.6 in S1 Appendix. Data shown here, and throughout the paper, are provided in the supporting information. Note how the worm pedigrees display clear, invariant patterns whereas the T-cell pedigrees (and the branching process) have no obvious repeatable structure.