Integration of single-cell RNA-seq data into population models to characterize cancer metabolism
Fig 5
Impact of boundary conditions on gene-deletion predictions for LCPT45 dataset.
A) Left: effect of gene deletions on the population growth rate, when exogenous palmitate uptake is allowed (purple bars) and when is not (green bars). Only genes with differential effect are reported. A missing bar indicate an essential gene (grRatio = 0). Right: effect of the deletion of gene HGNC:8808 on the growth rates of each single-cell. B) Left: effect of gene deletions on the population growth rate when exogenous lactate uptake is allowed (purple) and when is not (green). Right: effect of the deletion of gene HGNC:4458 on each single-cell. C) Left: effect of gene deletions on the population growth rate when endogenous glutamate release is allowed (purple) and when is not (green). Right: effect of the deletion of gene HGNC:29 on each single-cell.