Integration of single-cell RNA-seq data into population models to characterize cancer metabolism
Fig 4
Metabolic cooperation in LCPT45 population.
Left: Clustergram of the fluxes of cooperation reactions for NH3, lactate, glutamate and palmitate. Negative fluxes (blue shades) indicate an uptake, whereas positive fluxes (red shades) indicate a secretion of the corresponding metabolite. Right: Scatterplot of the biomass flux values of each cell in the population vs. palmitate (top) or vs. lactate cooperation flux (bottom).