Integration of single-cell RNA-seq data into population models to characterize cancer metabolism
Fig 3
Clustering of transcripts vs. fluxes.
A) LCPT45 dataset. Clustergram (distance metric: euclidean) of the transcripts of the metabolic genes included in metabolic network (left) and of the metabolic fluxes predicted by scFBA (middle). Right panel: elbow analysis comparing cluster errors for k ∈ {1, ⋯, 20} (k-means clustering) in both transcripts (blue) and fluxes (green). B) Same information as in A for the BC04 dataset.