Integration of single-cell RNA-seq data into population models to characterize cancer metabolism
Fig 2
A) Dataset LCPT45. Variability of the fraction of the biomass synthesis flux (logarithmic scale) for each cell over the population growth rate (left panel) before (purple) and after data integration (green). Effect of gene deletion (bars in right panel) on the population growth rate before (popFBA), after data integration (scFBA), and for the template metabolic network A* (bulkFBA). When grRatio = 0 (essential gene), the corresponding bar is not displayed. B) Same information as in A for BC04 dataset.