Integration of single-cell RNA-seq data into population models to characterize cancer metabolism
Fig 1
Graphical representation of scFBA.
Extracellular fluxes and sc-transcriptomes are translated respectively into type 1 and 2 heterogeneous constraints (see Materials and methods) imposed on a initially homogenous population of Ncells replicates of metabolic network A. The output is a heterogeneous set of flux patterns that may predict sc-fluxes.