Identifying individual risk rare variants using protein structure guided local tests (POINT)
Fig 5
Assessment of PCSK9-LDLR binding stability for the mutant sequences from the five POINT-identified loci using molecular dynamic simulations.
There are 8 mutant sequences observed in ACCORD samples, four of which have significant conformational fluctuation changes comparing to wildtype sequence: N157K, H553R, A443T+H391N, and A443T+N425S. P-values from Wilcoxon rank sum test of difference in RMSF are shown in parentheses.