Identifying individual risk rare variants using protein structure guided local tests (POINT)
Fig 4
A: Rare variant locations on the protein tertiary structure of PCSK9 binding with LDLR (shown in yellow). Promising variants (i.e., p-value<0.05) are shown in colored boxes, with variants found by both single variant test and POINT shown in red and variants found only by POINT shown in green and blue. B: Euclidean distance-based clustering of the variants.