Exploring chromatin hierarchical organization via Markov State Modelling
Fig 6
The major cluster in whole-genome partition interactions.
The nodes represent (A) partition sizes and (B) CTCF Z-scores. Tight sub-clusters of partitions show chromosomal territories, which are differentiated by the node colors characteristic for different chromosomes. Black edges between nodes represent scaffold-layer interactions, and grey edges, layer 1 interactions (see also S4 Fig and corresponding explanations on the classification of effective interaction strengths in “Data sets, processing, and visualization” of the Materials and Methods). The chromosomes that are not shown here form only single-chromosome clusters that do not strongly interact with chromosomes of the major cluster.