Dynamic filopodial forces induce accumulation, damage, and plastic remodeling of 3D extracellular matrices
Fig 4
ECM recruitment profiles from discrete network simulations showing dependence on loading forces and crosslink concentration.
(a) Normalized ECM concentration within the region 0–3μm from the cell vs. time (normalized by the duration of force application) for different loading forces (per fiber), as indicated by the arrows and color legend (in pN). (b) Peak normalized ECM concentration in the accumulation region as a function of the loading force. For the simulations of (a,b), the relative crosslink zero-force unbinding rate is 1x, the relative crosslink mechanosensitivity is 0.3x, and the relative crosslink density is 1x. (c) Normalized ECM concentration within the accumulation region vs. time for different relative crosslink concentrations, as indicated by the arrows and color legend. (d) Peak normalized ECM concentration in the accumulation region as a function of the relative crosslink concentration. In (c,d) the loading force is 100pN, the relative crosslink zero-force unbinding rate is 0.1x, and the relative crosslink mechanosensitivity is 0.3x. See S4 Fig for statistics of triplicate simulations for selected configurations. See S1 Table for 1x values of relative parameters.