CoPhosK: A method for comprehensive kinase substrate annotation using co-phosphorylation analysis
Fig 6
Performance of CophosK, KinomeXplorer and CophosK+ in predicting kinases for phosphosites.
For each dataset, we consider all phosphosites that are identified in the dataset and/or reported in PhosphoSitePlus. For each phosphosite, we perform leave-one-out cross validation by hiding the association between the phosphosite and one of its associated kinases (target kinase) to rank the likely kinases for the phosphosite using PUEL, CophosK, KinomeXplorer, and CophosK+. We report the fraction of phosphosites for which the target kinase is ranked in the top 1 and top 5 predicted kinases by each method (as indicated by different colors in the bar plot). Each panel shows the performance of the methods on (a) breast cancer PDX data(I), (b) ovarian cancer(II), (c) breast cancer(III), (d) breast cancer(IV), (e) ovarian cancer(V), and colorectal cancer(VI) datasets.