Chemogenomic model identifies synergistic drug combinations robust to the pathogen microenvironment
Fig 5
The drug-drug interaction landscape.
(a) The heat maps show the predicted impact of 9 distinct metabolic environments on the interaction outcomes of 2556 pairwise drug combinations (synergy (blue), antagonism (red)). The drug combinations and metabolic conditions are clustered based on similarity (Euclidean distance) and the dendrogram was plotted based on average linkage. Panel b shows the corresponding interaction scores for A. baumannii.