Dynamical differential expression (DyDE) reveals the period control mechanisms of the Arabidopsis circadian oscillator
Fig 4
DyDE applied to the Arabidopsis circadian oscillator genes.
(A) Common network and nu-gap analysis. The common network displays the models that have been validated in both untreated and NAM-treated plants. A directed arrow from gene a to gene b (blue circles), therefore, represents a dynamical model that captures the dependency of b on a. Red arrows represent the models associated with the top five highest nu-gap values. (B) Bar plot comparing the connectivity loss (%) associated to each gene. For a particular gene, the connectivity loss corresponds to the total amount of incoming and outgoing links that were validated in untreated plants but not in NAM-treated plants. Error bars represent the standard deviation of connectivity loss for ± 5% change in fitness threshold selection.