A computational model for gonadotropin releasing cells in the teleost fish medaka
Fig 4
Feature-based sensitivity analysis.
Sensitivity to variations in the maximum ion-channel conductances. The analysis summarizes a large number of simulations where the maximum conductances of all ion channels were varied within intervals ±50% of their original values. An exception was made for gBK, which was varied between 0 and 0.31 mS/cm2. Features were binary (0 or 1), and (A) IsBursting = 1 for simulations that elicited one or more bursts, (B) IsRegular = 1 for simulations that elicited one or more regular APs, and (C) IsNotSpiking = 1 for simulations that did not elicit any AP events. (A-C) Histograms depict the total-order Sobol sensitivity indices which quantify how much of the variability in a response features that is explained by the variation of a given model parameter, including all its co-variances with other parameters. The analysis was performed by aid of the recently developed toolbox Uncertainpy [36] (see Methods for details).