A computational model for gonadotropin releasing cells in the teleost fish medaka
Fig 2
(A1) INa in models of a medaka gonadotroph and a generic murine pituitary cell (G). INa had three activation gates (q3) and one inactivation gate (h). (B1) ICa activation in models of medaka gonadotrophs, generic murine pituitary cells (G), rat lactotrophs (RL), and rat somatotrophs (RS). Two activation gates were used in medaka (m2), and one in the other models. (C1) IK had one activation gate (n). (D1) IBK, had one activation gate (f), depending on voltage and domain [Ca2+], the latter assumed to be proportional to ICa. Results shown for ICa = 0, 10, 30 and 100 pA. (E1) ISK was Ca2+ activated with one activation gate s. (A2-B2) Voltage-dependent activation time constants were computed for INa (A2) and ICa (black curves), while all murine model used fixed time constants (red curves). Voltage-independent activation-time constants were used for IK (C2), IBK (D2) and ISK (E2). (A-E).