A mathematical model of calcium dynamics: Obesity and mitochondria-associated ER membranes
Fig 7
Effects of cellular changes associated with obesity on amplitudes of cytosolic and mitochondrial Ca2+ transients.
The control model and the obesity model was given a pulse of IP3, Eq 55 with M = 10, t0 = 100, and Δ = 0.2, shown by the inset graph in (A). The cytosolic Ca2+ trajectories are shown in (A), while mitochondrial Ca2+ are shown in (B). The blue solid curves are the solutions from the control model, and the red dashed ones are from the obesity model. The green dashed vertical lines indicate the pulsing time. The bottom panels show the quantification of (C) cytosolic and (D) mitochondrial Ca2+ FRET ratio peaks in wild type and ob/ob hepatocytes. The experimental data were obtained from Arruda et al. [9]. * Student’s t-test p-value < 0.05.