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A mathematical model of calcium dynamics: Obesity and mitochondria-associated ER membranes

Fig 4

Ca2+ oscillations generated from the model exhibit varying orders of magnitude in different compartments.

(A) The model was given continuous stimulation of IP3 with Ps = 0.3 μM. From the top, the panels show Ca2+ oscillations in the ER, the MAM, and the bulk cytosol. (B and C) The magnitudes of IPR Ca2+ fluxes from the ER to the bulk cytosol and the MAM, respectively, during the oscillations shown in (A).

Fig 4

doi: https://doi.org/10.1371/journal.pcbi.1006661.g004