A mathematical model of calcium dynamics: Obesity and mitochondria-associated ER membranes
Fig 2
Effects of increased MAMs on amplitude of mitochondrial Ca2+ activities.
The model was simulated with a pulse of IP3, Eq 55 with M = 10, t0 = 60, and Δ = 0.2, shown by the inset graph. The blue solid trajectory was simulated with (RS1, RS2) = (0.15, 0.15), while the red dashed spike was generated with the increased MAM surface ratios, (RS1, RS2) = (0.48, 0.48). The black solid curve represents experimentally traced mitochondrial Ca2+ dynamics in control Hepa 1-6 cells, while the black dashed line describes that in the cells expressed with synthetic linkers. The green dashed line indicates the onset of the pulse in the model, and the time at which the cells were treated with 100 μM of ATP in the experiment. The experimental traces were obtained from Arruda et al. [9].