Review: Precision medicine and driver mutations: Computational methods, functional assays and conformational principles for interpreting cancer drivers
Fig 4
Examples of experimental strategies to explore the functional consequences of mutations altering tumorigenesis, disease progression, and drug responses.
These include (A) RPPA technology, (B) integrated proteogenomic analysis, (C) high-throughput gateway-compatible enhanced yeast two-hybrid, and (D) CRISPR-Cas9 genome editing. LC-MS/MS, liquid chromatography—tandem mass spectrometry; RPPA, reverse-phase protein assay.