Review: Precision medicine and driver mutations: Computational methods, functional assays and conformational principles for interpreting cancer drivers
Fig 3
A flowchart representing the comprehensive framework to precision oncology.
Here, our focus is the process of the interpretation of the driver mutation using the databases in cancer biology, cancer pathways, and the distribution of the ensembles of protein conformation. The next process to match the driver mutations against drug databases and known drug-target interactions is not discussed in this paper.