Multiscale computational model of Achilles tendon wound healing: Untangling the effects of repair and loading
Fig 10
Schematic of the agent-based model of wound healing in the injured rat Achilles tendon.
(A) Chemokine difference between the wound space and surrounding tissue drives cell migration into the wound. (B) Healthy Achilles tendon adjacent to the top and bottom of the wound space was comprised of fibroblasts (blue ovals) and highly aligned collagen (grey). The wound space was initially cell-free. (C) Cells migrated, proliferated, and synthesized and deposited collagen to create scar tissue within the wound area. (D) Magnification of the boxed area in (C) shows that the cells have different alignments and shapes determined by the cell alignment model and interact with 10μm x 10μm collagen patches (grey boxes). Each patch stored information on local collagen density (grayscale tone) and collagen alignment (lines). Cell sizes have been increased for visibility in this schematic.