Multiscale computational model of Achilles tendon wound healing: Untangling the effects of repair and loading
Fig 7
Identical average stretch frequencies result in varying cell alignment predictions using cell model.
(A) Steady-state predicted alignment response curves for cells stretched in cycles of 6 hours at 1Hz followed by 6 hours of rest (0Hz) (purple), cycles of 1 hour at 1Hz followed by 1 hour of rest (orange), and continuous stretching at 0.5Hz (green). (B) Detailed time course of predicted alignment during 24 hours of intermittent stretch using two different duty cycles and a strain amplitude of 0.10. Each strain protocol was repeated until the difference in alignment at the end of two consecutive repetitions was less than 0.01.