Multiscale computational model of Achilles tendon wound healing: Untangling the effects of repair and loading
Fig 2
Model predictions of collagen alignment and content match trends in tissue-level properties reported in the literature during healing of unrepaired tendons.
(A) Schematic of rat Achilles tendon transection injuries left to heal naturally. (B,C,E,F) We plotted data from studies (various colors) in which tendons healed unloaded (B,E) or loaded (C,F). We compared our predictions of collagen alignment (D) and content (G) to experimentally measured Young’s Moduli (B,C) and cross-sectional areas (E,F), see text for details.