Multiscale computational model of Achilles tendon wound healing: Untangling the effects of repair and loading
Fig 1
Flowchart depicting multiscale model.
(A) OpenSim model of rat hindlimb adapted from Johnson 2008 [16] simulates strains in the injured Achilles tendon. (B) Cell model predicts alignment based on the mechanical environment. (C) Fitted mean strain versus collagen I production curve (grey line) from four independent studies governs collagen production. (D) Agent-based model (ABM) of wound healing integrates migration, alignment, and collagen deposition by cells (blue) to predict scar collagen content and alignment (grey).