Protein ensembles link genotype to phenotype
Fig 2
Network perturbations of genotype–phenotype.
Mutations can shift phenotype traits generated from wild-type trait (upper panel), affecting solely the protein (a “node”) or protein–protein interaction (an “edge”). The former and latter are node and edge mutations, respectively. The node mutation (middle panel) generates a monogenetic trait, whereas the edge mutation (bottom panel) creates or breaks the protein–protein interactions yielding monogenetic or polygenetic traits. An example shown for edge trait is polygenetic.