Molecular basis for the increased affinity of an RNA recognition motif with re-engineered specificity: A molecular dynamics and enhanced sampling simulations study
Fig 6
(A) Bird’s-eye view of the Rbfox*•pre-miR20b* complex. (B) and (C) Close-up views of the interactions established by the mutated residues with A30 and C33, respectively. (D) Scheme of the interactions between pre-miR20b* and Rbfox* observed in the MD simulations. Circle and arrowheads depict interaction with RNA bases or phosphate groups, respectively.